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Does Kratom cause heart problems and related diseases?

Does Kratom cause heart problems and related diseases?

April 1, 2025
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Kratom & Me
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Hidden Valley Botanicals

Is your morning Kratom tea potentially setting you up for heart problems?

Are those Kratom capsules affecting your blood pressure in ways you haven't noticed?

Kratom has become increasingly popular among individuals seeking natural alternatives for pain management, mood enhancement, and even opioid withdrawal symptoms. But as this Southeast Asian plant gains traction in Western markets, questions about its safety - particularly regarding cardiovascular health - have surfaced with growing urgency.

Many consumers report concerning symptoms like Kratom heart palpitations while medical professionals are documenting cases of Kratom hypertension in clinical settings. These reports raise important questions about the relationship between Kratom and cardiovascular health that deserve careful examination.

If you're new to the herbal leaf, you might first want to check out everything you need to know about Kratom. Let’s examine the evidence behind Kratom heart health concerns to help you make informed decisions about your wellness routine.

How Kratom affects the body

Kratom works in your system through its active compounds - primarily mitragynine and 7-hydroxymitragynine - which interact with various receptors in your brain and body. What makes Kratom fascinating and potentially concerning for Kratom heart health is its dose-dependent effects.

At lower doses (typically 1–5 grams), Kratom acts as a stimulant. Similar to your morning coffee, it can increase energy, enhance focus, and boost sociability. This happens because Kratom alkaloids influence your adrenergic system and affect neurotransmitters like dopamine and serotonin. During this stimulant phase, some users report Kratom heart palpitations, which may feel like fluttering or racing heartbeats.

When taken in higher amounts (5–15 grams), Kratom shifts dramatically to produce sedative and pain-relieving effects. This occurs as the alkaloids bind more strongly to opioid receptors, creating sensations similar to conventional opioids but through slightly different mechanisms.

This dual nature explains why Kratom's impact on cardiovascular health isn't straightforward. The stimulating effects can temporarily increase blood pressure and heart rate, while the sedative effects at higher doses might cause irregular heartbeats in some individuals. Research suggests that regular high-dose consumption may affect lipid profiles and potentially strain the cardiovascular system over time.

Your body's individual response to Kratom depends on factors like your overall health, genetics, frequency of use, and whether you mix Kratom with other substances - all critical considerations when evaluating its safety for your heart.

Kratom and heart palpitations

Heart palpitations - those moments when your heart feels like it's fluttering, pounding, or skipping beats - are among the most commonly reported cardiovascular concerns among Kratom consumers. These sensations, while often temporary and harmless, can be frightening and may signal underlying issues that deserve attention.

The connection between Kratom and heart palpitations likely stems from its pharmacological action. At lower doses, Kratom stimulates alpha-2 adrenergic receptors and affects serotonin and dopamine pathways, creating stimulant-like effects similar to caffeine. This stimulation can increase your heart rate and contractility, potentially triggering palpitations in sensitive individuals.

The risk factors that may increase your chances of experiencing heart palpitations from Kratom include:

  • Using high doses (typically above 5 grams);
  • Combining kratom with other stimulants like caffeine;
  • Pre-existing heart conditions;
  • Dehydration;
  • Individual sensitivity to kratom's alkaloids.

It's worth noting that many clinical cases involving severe Kratom heart problems often involve polysubstance use or underlying health conditions, making it difficult to isolate Kratom as the sole cause. However, the consistency of cardiovascular symptoms across various reports suggests caution is warranted, especially for those with pre-existing heart conditions.

Effects of Kratom on blood pressure

Kratom's relationship with blood pressure represents one of the more complex aspects of its physiological effects. Unlike substances with predictable cardiovascular impacts, the effects of Kratom on blood pressure vary significantly based on dosage, individual physiology, and frequency of use.

At lower doses (typically 1–5 grams), Kratom functions primarily as a stimulant. This stimulant action activates adrenergic receptors in your body, potentially causing vasoconstriction - a narrowing of blood vessels that can increase blood pressure. This mechanism is similar to how caffeine temporarily raises blood pressure, though Kratom's effects may last longer due to its complex alkaloid profile.

However, at higher doses (above 5–15 grams), Kratom shifts toward opioid-like effects, which can sometimes lower blood pressure through vasodilation and sedation. This biphasic action creates an unpredictable cardiovascular response that makes Kratom hypertension a legitimate concern for certain users.

For individuals already managing high blood pressure, this unpredictability presents a significant risk. The temporary spikes in blood pressure from Kratom could potentially:

  • Strain arterial walls, contributing to vessel damage over time;
  • Increase the workload on your heart muscle;
  • Interfere with prescribed blood pressure medications;
  • Trigger cardiovascular events in high-risk individuals.

Studies suggest regular Kratom consumers may experience changes in lipid profiles, including elevated LDL cholesterol. This can indirectly worsen hypertension and increase the risk of heart disease. The relationship between Kratom and the heart becomes even more concerning for those with preexisting cardiovascular conditions like arrhythmias, coronary artery disease, or heart failure.

If you have a history of heart problems or hypertension and choose to use Kratom, regular monitoring of your blood pressure is essential. Maintain open communication with your healthcare provider about your Kratom use.

Can Kratom cause heart attacks or other cardiovascular issues?

There is no definitive proof that Kratom directly causes attacks, but scientific reports suggest potential cardiovascular risks. Most serious cases occur in consumers with specific risk factors, including high doses, frequent use, polysubstance interactions and preexisting heart conditions.

Case reports have linked Kratom to cardiovascular events. One example involved a young adult who developed high-output heart failure and pulmonary hypertension after daily use, with symptoms improving after quitting.

Kratom’s stimulant effects at lower doses can elevate heart rate and blood pressure, increasing cardiac workload. Some studies indicate its alkaloids may prolong QTc intervals, raising the risk of arrhythmias.

Additionally, Kratom may influence hormone levels, which could play a role in its cardiovascular impact. Research suggests a connection between Kratom and hormones, particularly its effects on testosterone and other key regulators. Chronic use has also been linked to unfavorable lipid changes that may contribute to atherosclerosis.

However, research is limited, relying on case reports and animal studies rather than controlled trials. Many severe cases involve other substances, complicating conclusions. Interestingly, long-term consumers in Malaysia report fewer cardiovascular issues, possibly due to differences in consumption or metabolism.

Those with heart conditions, those on medications affecting heart rhythm, or anyone experiencing chest pain or palpitations while using Kratom should consult a healthcare provider.

Safe Kratom use and dosage considerations

Using Kratom responsibly can help reduce cardiovascular risks. Lower doses (1–5 grams) generally have milder effects, while higher doses may increase heart palpitations and blood pressure changes. To protect your heart, have a solid understanding of how to identify the ideal dosage and follow these tips:

  • Start with minimal doses (under 2 grams) to gauge sensitivity.
  • Avoid exceeding 5 grams per dose, especially if you have heart conditions.
  • Space out doses to prevent strain on the cardiovascular system.
  • Stay hydrated and take breaks to avoid tolerance buildup.

Mixing Kratom with caffeine, alcohol or medications heightens cardiovascular risks. Stick to pure, lab-tested Kratom, as found at Hidden Valley Botanicals, for better safety. Those with heart conditions should consult a doctor and monitor their heart rate and blood pressure if they choose to use Kratom.

Beyond heart health, Kratom may affect hormones, potentially lowering libido, altering energy levels and impacting testosterone.

Neurologically, Kratom can improve mood and pain relief but may cause cognitive impairment or, in rare cases, seizures at high doses. Digestive issues, like constipation, are common, and potential liver impacts remain under study.

Regular health monitoring, including blood work and cognitive tracking, ensures safer long-term use.

The relationship between Kratom and the heart requires a nuanced understanding rather than blanket statements about safety or danger. Current evidence suggests that Kratom can indeed influence cardiovascular function. This is particularly true with heart palpitations, blood pressure changes, and potentially more serious conditions in susceptible individuals or with excessive use.

The risks appear highest for those with preexisting heart conditions, consumers who take high doses, and those who combine Kratom with other substances. Conversely, moderate, informed use with careful monitoring appears to carry lower risks for healthy individuals.

Given the gaps in research and the uniqueness of each person’s physiology, consulting with a healthcare professional is prudent. Especially for those with heart conditions or experiencing unusual symptoms.

Stay informed about emerging research and practice moderations, always prioritizing your heart health above all experiential benefits. Your cardiovascular system is simply too important to gamble with.

Final thoughts: caution is always advised

If you're thinking about trying Kratom but are wary of side-effects and health issues, start out with a beginner-friendly strain such as a Green Vein Kratom strain in the lowest recommended dose. Remember, certain colors will stimulate while others sedate, so have clear wellness goals in mind when selecting the Kratom strain.

Green Kratom strains tend to offer the best of both worlds where effects are concerned so make a good starting point on your Kratom journey. Below this blog you'll find some of our favorite Green Vein strains which are available in both capsule and powder form from Hidden Valley Botanicals.

If at any point you experience unsual effects or sensations after taking Kratom, cease consumption immediately and consult your healthcare professional. It is always better to be safe than sorry.

Green vein Kratom strains great for beginners

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